with activity and may have a recognizable pattern.

Pain from a serious underlying bone problem may behave differently.

For example, concerning features can include pain that:

• Persists without a clear explanation
• Gradually becomes worse
• Occurs even when resting
• Interferes with sleep
• Is not improving as expected after an injury

None of these features proves cancer.

But persistent unexplained pain deserves evaluation rather than indefinite self-treatment.

Swelling or a New Lump Can Also Matter

Another possible warning sign is swelling around the affected area.

A person may notice that one knee

There’s more to discover. Continue to the next page for the rest of this article.